Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets
Eliana Sherman, Kevin Qiu, Rebecca Roberts, Lucille Shichman, Sihan Li, Huayu Sun, Lucie Ide, Allison Tucker, Seonjoo Lee, Weronika Gniadzik, Jung Bum Shin, Katia Sol‐Church, Jaideep Kapur, Aiying Zhang, Alev Erişir, , the Alzheimer’s Disease Neuroimaging Initiative
The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.
bioRxiv · Oct 17, 2025 · PreprintNeuroscience