NeurosciencebioRxivPreprint
Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets
Eliana Sherman, Kevin Qiu, Rebecca Roberts…·the Alzheimer’s Disease Neuroimaging Initiative
The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.