ACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection
Wenjie Fu, Yanlan Gao, Yanqing Fang, Linlong Guo, Yalu Huang, Luyao Hong, 陆斌兴, Ziru Li, 鄢来香, Bin Hu, Chaoyun Wang, Lin Zhong, Min Chen, Y Li
This study shows ACAN promotes aortic dissection by disrupting mitochondrial homeostasis in VSMCs via the YAP1/TAZ pathway, and its reduction improves disease outcomes.
bioRxiv · Sep 21, 2026 · PreprintPharmacology & Toxicology