TLR priming licenses NAIP inflammasome activation by immunoevasive ligands
James P. Grayczyk, Luying Liu, Marisa S. Egan, Emily Aunins, Meghan A. Wynosky-Dolfi, Scott Canna, Andy J. Minn, Sunny Shin, Igor E. Brodsky
This study shows TLR priming increases NLRC4 expression in murine macrophages, enabling detection of immunoevasive NAIP ligands, while human macrophages lack this response.
Proceedings of the National Academy of Sciences · Nov 18, 2024Peer-reviewedMolecular Biology