Functional metagenomics reveals an alternative, broad-specificity pathway for metabolism of carbohydrates in human gut commensal bacteria
Seyed A. Nasseri, Aleksander C. Lazarski, Imke L. Lemmer, Chloe Y. Zhang, Eva Brencher, Hongming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, L.J. Worrall, Harry Brumer, Natalie C. J. Strynadka, Stephen G. Withers
The paper identifies a novel, broad-specificity glycosidase pathway in gut bacteria that operates via a non-Koshland mechanism, capable of hydrolyzing diverse substrates including thioglycosides and pharmaceuticals.
Nature · Jun 19, 2024Peer-reviewedBiochemistry