Author

M. A. Gregory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

H. J. Park· 2 shared J. DeGregori· 2 shared V. Zaberezhnyy· 2 shared A. D Alessandro· 1 shared A. Goodspeed· 1 shared C. T. Jordan· 1 shared J. S. Kieft· 1 shared K. C. Hansen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

H. J. Park

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2 papers

Recent·Most cited

Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

H. J. Park, M. A. Gregory, V. Zaberezhnyy, A. Goodspeed, C. T. Jordan, J. S. Kieft, J. DeGregori

The paper shows that marrow-mediated activation of ATM and mTOR increases oxidative phosphorylation, leading to resistance in FLT3 mutant AML cells, and that combining mTOR and FLT3 inhibitors reduces tumor burden.

bioRxiv · Feb 14, 2022Cancer Biology

Targeting glutamine metabolism and redox state for leukemia therapy

M. A. Gregory, T. Nemkov, V. Zaberezhnyy, H. J. Park, S. Gehrke, K. C. Hansen, A. D Alessandro, J. DeGregori

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.

bioRxiv · Apr 18, 2018Cancer Biology