MicrobiologybioRxiv
Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.
C. H. P. Cheung, M. Alorabi, F. Hamilton…·M. B. Avison
The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.
DOI 10.1128/aac.02412-20