Author

F. Hamilton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Assay:DNA methylation· 1

Frequent Co-Authors

K. J. Heesom· 3 shared A. D. Davidson· 2 shared D. Arnold· 2 shared M. B. Avison· 2 shared O. Mounsey· 2 shared P. B. Williams· 2 shared Y. Takebayashi· 2 shared A. Milne· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

K. J. Heesom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

P. Dulyayangkul, T. Beavis, W. W. Lee, R. Ardagh, F. Edwards, F. Hamilton, I. Head, K. J. Heesom, O. Mounsey, M. Murarik, C. Reding, N. Satapoomin, J. M. Shaw, Y. Takebayashi, C. L. Tooke, , M. B. Avison

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

bioRxiv · Dec 2, 2023 · PreprintMicrobiology

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

L. J. Goudswaard, C. M. Williams, J. Khalil, K. L. Burley, F. Hamilton, D. Arnold, A. Milne, P. A. Lewis, K. J. Heesom, S. J. Mundell, A. D. Davidson, A. W. Poole, I. Hers

This study identifies altered platelet proteome and impaired integrin αIIbβ3 activation in COVID-19 patients, linked to increased platelet-neutrophil aggregates and thromboinflammation.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

E. Avolio, M. Carrabba, R. Milligan, M. Kavanagh Williamson, A. P. Beltrami, K. Gupta, K. T. Elvers, M. Gamez, R. Foster, K. Gillespie, F. Hamilton, D. Arnold, I. Berger, M. Caputo, A. D. Davidson, , P. Madeddu

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

bioRxiv · Dec 21, 2020Cell Biology

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.

C. H. P. Cheung, M. Alorabi, F. Hamilton, Y. Takebayashi, O. Mounsey, K. J. Heesom, P. B. Williams, M. Williams, M. Albur, A. P. MacGowan, M. B. Avison

The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.

bioRxiv · Oct 24, 2020Microbiology