Identification of CRYAB+ KCNN3+ SOX9+ astro-like and EGFR+ PDGFRA+ OLIG1+ oligo-like tumoral cells in diffuse low-grade gliomas and implication of Notch1 signalling in their genesis
M. Augustus, D. Pineau, F. Aimond, S. Azar, D. Lecca, N. Leventoux, F. Scamps, S. Muxel, A. Darlix, W. Ritchie, C. Goze, V. Rigau, H. Duffau, J.-P. Hugnot
The paper identifies two distinct tumoral cell subtypes in IDH1-mutated low-grade gliomas and shows NOTCH1 signaling influences their characteristics.
bioRxiv · Feb 9, 2021Cancer Biology