Cell BiologybioRxivPreprint
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
G. L. Pearson, E. M. Walker, N. Lawlor…·S. A. Soleimanpour
This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.
DOI 10.1101/2022.08.02.502357