D. Zhang

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Splicing accuracy varies across human introns, tissues and age

The paper examines mis-splicing across human introns, tissues, and age using RNA-sequencing data, finding correlations with spliceosome components and age-related neurodegenerative disease genes.

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides

This study identifies diverse ribosomally synthesized peptides in the human microbiome and shows some inhibit pathogens and reduce inflammation.

Systematically investigating and identifying bacteriocins in the human gut microbiome

The paper introduces IIBacFinder to identify unmodified class II bacteriocins in the human gut microbiome, showing their widespread distribution and biosynthetic potential.

IsRNAcirc: 3D structure prediction of circular RNAs based on coarse-grained molecular dynamics simulation

IsRNAcirc predicts circular RNA 3D structures using coarse-grained molecular dynamics, outperforming template-based methods on a validation set.

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

Single-Cell Transcriptomic Analysis Highlights Specific Cell Types of Wheat Manipulated by Fusarium graminearum Leading to Susceptibility

This study uses single-cell RNA sequencing to analyze wheat cell responses to adapted and non-adapted fungal pathogens, identifying specific cell types involved in susceptibility and resistance.

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model

This study uses a CRISPR-dCas9 model to investigate the BFB cycle, revealing increased DNA damage, chromosome fusions, and involvement of DNA repair pathways in ITCB formation.

Balancing the risks of mating: biogeographic evidence of cleistogamy as a bet hedging strategy

This study examines cleistogamy as a bet hedging strategy by analyzing biogeographic patterns across 400 species, finding it more common in cooler, variable environments.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)

This study analyzed antibiotic resistance, virulence genes, and molecular epidemiology of CRKP strains from giant pandas, revealing diverse genetic profiles and high genetic diversity.

Reductive dehalogenation by diverse microbes is central to biogeochemical cycles in deep-sea cold seeps

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats

The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

Middle-infrared Modulation Of Sleep By Cardiometabolic Function

This study shows that middle-infrared radiation improves sleep by enhancing blood circulation and reducing homocysteine and T-cell levels, linking cardiometabolic function to sleep quality.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

Boosting Ascomycin Production through n-Butanol Addition in the Fermentation Process of Streptomyces hygroscopicus var. ascomyceticus ATCC 14891

This study enhances FK520 production in Streptomyces hygroscopicus by adding n-butanol, increasing yield by 1.72-fold and boosting precursor accumulation.

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

Fusarium graminearum Ste2 and Ste3 Receptors Undergo Peroxidase Induced Heterodimerization

This study shows that FgSte2 and FgSte3 GPCRs in F. graminearum form heterodimers in response to peroxidase and HRP-derived ligands, using bioluminescence resonance energy transfer and affinity pulldown.