Author

E. M. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

B. A. Kaufman· 2 shared E. C. Reck· 2 shared E. Levi-D'Ancona· 2 shared G. L. Pearson· 2 shared J. Zhu· 2 shared S. A. Soleimanpour· 2 shared V. Sidarala· 2 shared A. B. Osipovich· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

B. A. Kaufman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

J. Cha, X. Tong, E. M. Walker, T. Dahan, V. Cochrane, S. Ashe, R. Russell, A. B. Osipovich, A. M. Mawla, M. Guo, J.-h. Liu, M. O. Huising, M. A. Magnuson, M. Hebrok, Y. Dor, R. Stein

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

bioRxiv · Oct 20, 2022Cell Biology

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

G. L. Pearson, E. M. Walker, N. Lawlor, A. Lietzke, V. Sidarala, J. Zhu, T. Stromer, E. C. Reck, A. M. Stendahl, J. Li, E. Levi-D'Ancona, M. B. Pasmooij, D. L. Hubers, A. Renberg, K. Mohamed, , S. A. Soleimanpour

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

bioRxiv · Aug 2, 2022 · PreprintCell Biology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

V. Sidarala, J. Zhu, E. Levi-D'Ancona, G. L. Pearson, E. C. Reck, E. M. Walker, B. A. Kaufman, S. A. Soleimanpour

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.

bioRxiv · Jan 10, 2021 · PreprintCell Biology