Lyn controls chemotaxis and motility of CLL cells via phosphorylation of ROR1.
Z. Dave, O. Vondalova-Blanarova, S. Cada, P. Janovska, N. Zezula, M. Behal, K. Hanakova, S. R. Ganjani, P. Krejci, K. Gmöryöva, H. Peschelova, M. Smida, Z. Zdrahal, S. Pavlova, J. Kotaskova, , V. Bryja
This study shows Lyn phosphorylates ROR1, affecting its surface levels and migratory properties in CLL cells, linking BCR and ROR1 signaling.
bioRxiv · May 29, 2020Cancer Biology