Z. Zdrahal

The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.

This study identifies CDKD;3 as a gene that suppresses meiotic defects in smg7 mutants by promoting meiotic exit and enabling cytokinesis in Arabidopsis.

This study shows RNF43 inhibits WNT5A signaling and suppresses melanoma invasion by ubiquitinating VANGL2 and internalizing ROR1, leading to worse prognosis in RNF43-low patients.

This study shows Lyn phosphorylates ROR1, affecting its surface levels and migratory properties in CLL cells, linking BCR and ROR1 signaling.

The paper investigates the catalytic potential of a (GGC)3 nonamer by showing thermal treatment produces a (GGC)3G species and supports transient geometries compatible with terminal recombination chemistry.

This study uses laser capture microdissection and mass spectrometry to identify tissue-specific proteomes in Eudiplozoon nipponicum, revealing 2,059 proteins and confirming the presence of cathepsin L in the intestine.

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

This study identifies multiple TTBK2 substrates and their phosphorylation sites, showing their role in ciliogenesis and revealing distinct phosphorylation motifs.

The study compares DVL3 phosphorylation by eight kinases and identifies kinase-specific phosphorylation signatures.