Identification of non-conventional small molecule degraders and stabilizers of squalene synthase
J. G. F. Hoock, C. Rossetti, M. Bilgin, L. Depta, K. Enemark-Rasmussen, J. C. Christianson, L. Laraia
This study identifies small molecules that either degrade or stabilize squalene synthase, showing that degradation is possible despite challenges and providing a foundation for future probe development.
Chemical Science · Jan 1, 2023Peer-reviewedCell Biology