L. Depta

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

The paper profiles fluorescent steroid probes across ten STPs to uncover selectivity differences and establishes a screening panel to identify new Aster-B inhibitors.

Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

This study identifies small molecules that either degrade or stabilize squalene synthase, showing that degradation is possible despite challenges and providing a foundation for future probe development.