Inhibition of the type IV secretion system from antibiotic-resistant Helicobacter pylori clinical isolates supports the potential of Cagα as an anti-virulence target
F. Oudouhou, C. Morin, M. Bouin, C. Gaudreau, C. Baron
The paper investigates the genetic variability of the cagPAI in antibiotic-resistant H. pylori strains and shows that a small molecule inhibitor reduces interleukin-8 secretion and T4SS pili assembly.
bioRxiv · Sep 1, 2023 · PreprintMicrobiology