Author

C. Baron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

B. Bessette· 2 shared B. Casu· 2 shared C. Morin· 2 shared F. Oudouhou· 2 shared J. Amro· 2 shared J. Sygusch· 2 shared T. Arya· 2 shared V. T. Verma· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

B. Bessette

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori

C. Morin, V. T. Verma, T. Arya, B. Casu, E. Jolicoeur, R. Ruel, A. Marinier, J. Sygusch, C. Baron

The paper designs small molecule inhibitors of the cagT4SS ATPase Cagα in Helicobacter pylori using structure-based approaches and identifies five potent inhibitors that inhibit ATPase activity and T4SS pili assembly.

bioRxiv · Nov 6, 2023Biochemistry

Inhibition of the type IV secretion system from antibiotic-resistant Helicobacter pylori clinical isolates supports the potential of Cagα as an anti-virulence target

F. Oudouhou, C. Morin, M. Bouin, C. Gaudreau, C. Baron

The paper investigates the genetic variability of the cagPAI in antibiotic-resistant H. pylori strains and shows that a small molecule inhibitor reduces interleukin-8 secretion and T4SS pili assembly.

bioRxiv · Sep 1, 2023 · PreprintMicrobiology

TraC of the conjugative plasmid pKM101 is secreted as a monomer in outer membrane vesicles and stimulates conjugation

J. Amro, C. Baron

The paper characterizes the TraC protein from plasmid pKM101, showing it is secreted as a monomer in outer membrane vesicles and contributes to conjugation at the cell-cell contact stage.

bioRxiv · Jul 29, 2022 · PreprintMicrobiology

Cryo-EM structure of the Agrobacterium tumefaciens T-pilus reveals the importance of positive charges in the lumen

J. Amro, C. Black, Z. Jemouai, N. Rooney, C. Daneault, N. Zeytuni, M. Ruiz, K. H. Bui, C. Baron

The paper reports cryo-EM structures of Agrobacterium tumefaciens T-pilus and related N-pilus, showing positive charges in the lumen are functionally important.

bioRxiv · Apr 28, 2022Biochemistry

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

S. Ding, S. Y. Gong, J. Grover, M. Mohammadjavad, Y. Chen, D. Vezina, G. Beaudoin-Bussieres, V. T. Verma, G. Goyette, J. Richard, D. Yang, A. B. Smith, M. Pazgier, M. Cote, C. Abrams, , C. Baron

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

bioRxiv · Feb 3, 2022Microbiology

Acidity and sulfur oxidation intermediate concentrations controlled by O2-driven partitioning of sulfur oxidizing bacteria in a mine tailings impoundment

K. J. Whaley-Martin, L.-X. Chen, T. Colebrander Nelson, J. Gordon, R. Kantor, L. E. Twible, S. Marshall, L. Rossi, B. Bessette, C. Baron, S. Apte, J. Banfield, L. A. Warren

The paper investigates sulfur oxidation by bacteria in a mine tailings impoundment, showing how oxygen drives niche partitioning among sulfur-oxidizing bacteria and affects acidity and thiosulfate levels.

bioRxiv · Sep 16, 2021 · PreprintMicrobiology

Fragment-based screening identifies inhibitors of the ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

T. Arya, F. Oudouhou, B. Casu, B. Bessette, J. Sygusch, C. Baron

The paper identifies inhibitors of Cagα's ATPase activity and hexamer formation using fragment-based screening, revealing a novel mechanism for antivirulence drug development.

bioRxiv · May 20, 2018Microbiology