Cell BiologybioRxivPreprint
Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
A. Mamais, N. Landeck, R. G. Langston…·M. R. Cookson
This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.
DOI 10.1101/2020.07.27.219501