Author
National Institutes of HealthPrimary ORCID profile (0000-0002-1058-3831 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
M. C. Mazza, S. Shuck, J. Lin…·M. A. Wilson
This study investigates DJ-1's role in glycation defense and finds it has only a minor effect on reducing methylglyoxal damage in neurons.
M. C. Mazza, V. Nguyen, A. Beilina…·M. R. Cookson
This study shows that double knockout of Lrrk2 and Rab29 in mice does not lead to significant behavioral or dopamine neuron loss, suggesting the pathway can be safely targeted therapeutically.
J. H. Kluss, A. Beilina, C. D. Williamson…·L. Bonet-Ponce
This study shows that lysosomal positioning regulates LRRK2-dependent Rab10 phosphorylation, with phosphatase activity modulating this process in perinuclear lysosomes.
A. Mamais, N. Landeck, R. G. Langston…·M. R. Cookson
This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.
Janel O. Johnson, Ruth Chia, Danny E. Miller…·Bryan J. Traynor
The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.
L. Bonet-Ponce, A. Beilina, C. Williamson…·M. R. Cookson
This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.
C.-X. Wu, J. Liao, Y. Park…·Q. Q. Hoang
This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.