C. Kim

De novo chemo-optogenetics through rational small-molecule design and TRAP display

This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.

Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress

This study investigates how chronic short sleep affects metabolism and survival under oxidative stress in mutants, finding common metabolic defects and suggesting lipid metabolism issues may underlie oxidative stress sensitivity.

A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism

This study shows that a ketogenic diet enhances the effectiveness of glutamine metabolism inhibitors in pancreatic cancer by increasing tumor reliance on glutamine for energy.

Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy

This paper develops a deep learning method to automate measurement of glomerular basement membrane and podocyte foot process widths in TEM images of podocytopathy mouse models, showing comparable accuracy to manual methods.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.

Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

This study identifies Msi2 as a key regulator in lung cancer initiation and progression, showing its dual role in sensitizing cells to transformation and driving tumor growth.

The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

This study identifies substrate preferences and regulatory mechanisms of TTLL glycylases, showing how tubulin glutamylation and polyglycylation influence TTLL10 activity and microtubule modification.

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

GENOMES UNCOUPLED1: an RNA-binding protein required for early PSII biogenesis

This study identifies psbD BLRP as a target RNA of GUN1, an RNA-binding protein essential for early PSII biogenesis during seedling development.

Fibronectin: a natural barrier against prion infection

This study identifies fibronectin as a natural barrier against prion infection by showing its association with PrPSc and its ability to reduce prion infectivity in vitro and in tissues.

Macrophages sense ECM mechanics and growth factor availability through cytoskeletal remodeling to regulate their tissue repair program

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

This paper develops APB-R3, a long-acting IL-18 blocker, showing efficacy in reducing inflammation in macrophage activation syndrome and atopic dermatitis models.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

A biophysical framework for double-drugging kinases

This study develops a biophysical framework to analyze double-drugging of kinases, revealing cooperative effects between orthosteric and allosteric inhibitors and providing structural insights.

Conservation implications of elucidating the Korean wolf taxonomic ambiguity through whole-genome sequencing

This study uses whole-genome sequencing to resolve the taxonomic status of the Korean wolf, finding it genetically similar to other East Asian wolves and not a distinct lineage.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

Pollen accumulation on hawkmoths varies substantially among moth-pollinated flowers

The study examines pollen accumulation on hawkmoths across different flower species, finding large variation in pollen deposition and loss, influenced by pollen stickiness and visitation frequency.

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer

This study identifies PARPi-induced degradation of lineage-specific oncoproteins as a mechanism for PARP1 inhibitor toxicity in SCLC, showing improved cytotoxicity when combined with targeted agents.

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

The paper evaluates neutralisation resistance of Omicron sublineages BA.2.75.2, BA.4.6, and BA.2.10.4, finding BA.2.75.2 shows extensive escape from neutralising antibodies.

ACCELERATING ANTIBODY DESIGN WITH ACTIVE LEARNING

The paper develops a sequence generation model using transfer and active learning to efficiently discover binding antibodies with novel HCDR3 regions, requiring only six thousand data points per antigen.

Reduced oocyte quality and exacerbation of the maternal age effect are enduring consequences of low-level atrazine exposure in mouse

This study shows that low-level atrazine exposure in mice impairs oocyte quality and worsens age-related aneuploidy, with effects lasting long after exposure ends.

Natriuretic peptides increase cGMP around cardiomyocyte mitochondria and protect against apoptosis

This study shows natriuretic peptides increase cGMP around cardiomyocyte mitochondria and reduce apoptosis through mitochondrial protection mechanisms.

Evasion of neutralizing antibodies by Omicron sublineage BA.2.75

This study evaluates the neutralization sensitivity of the SARS-CoV-2 BA.2.75 sublineage to monoclonal antibodies and sera from individuals infected with earlier variants.