A High-Fat and Fructose Diet in Dogs Mirrors Insulin Resistance and β-cell Dysfunction Characteristic of Impaired Glucose Tolerance in Humans
J. M. Gregory, G. Kraft, C. D. Man, J. C. Slaughter, M. F. Scott, J. R. Hastings, D. Edgerton, M. C. Moore, A. D. Cherrington
This study shows that a high-fat and fructose diet in dogs causes insulin resistance and β-cell dysfunction similar to human impaired glucose tolerance and type 2 diabetes.
bioRxiv · Oct 19, 2023 · PreprintPhysiology