Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.
N. Alzahofi, C. L. Robinson, T. Welz, E. L. Page, D. A. Briggs, A. K. Stainthorp, J. Reekes, D. A. Elbe, F. Straub, E. W. Tate, P. S. Goff, E. V. Sviderskaya, M. Cantero, L. Montoliu, M. Bailly, , A. N. Hume
The paper shows Rab27a recruits SPIRE1/2 to melanosomes, linking motor and track assembly proteins to enable long-range organelle transport via actin tracks.
bioRxiv · May 3, 2018Cell Biology