Ordered and disordered regions of the Origin Recognition Complex (ORC) combine to direct in-vivo binding at symmetric and non-symmetric motif sequences.
M. Chappleboim, S. Naveh-Tassa, M. Carmi, Y. Levy, N. Barkai
The paper identifies ORC elements that guide DNA binding in vivo, showing disordered basic patches are key for motif recognition at replication origins and silencing sites.
bioRxiv · Jan 27, 2024 · PreprintCell Biology