Y. Levy

In vivo imaging of autophagy dynamics in the intact mammalian brain using a fluorescence lifetime-based sensor

The paper develops a fluorescence lifetime-based sensor to image autophagy dynamics in vivo, revealing spatial and activity-dependent patterns in the mouse brain.

Ordered and disordered regions of the Origin Recognition Complex (ORC) combine to direct in-vivo binding at symmetric and non-symmetric motif sequences.

The paper identifies ORC elements that guide DNA binding in vivo, showing disordered basic patches are key for motif recognition at replication origins and silencing sites.

Rapid long-distance migration of RPA on single stranded DNA occurs through intersegmental transfer utilizing multivalent interactions

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

Sound-mediated nucleation and growth of amyloid fibrils

This study shows low-amplitude ultrasound can induce amyloid fibril nucleation and controlled growth from natively folded lysozyme monomers.

Muscle fibre size and myonuclear positioning in trained and aged humans

The paper examines how age and physical activity affect muscle fibre size, myonuclear numbers, and myonuclear domain volumes in humans, finding that exercise preserves fibre size and MND relationships while inactivity reduces fibre size and disrupts these relationships.

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

Allochthonous groundwater microorganisms affect coastal seawater microbial abundance, activity and diversity

This study shows that groundwater microbes influence coastal seawater microbial abundance, activity, and diversity through nutrient and microbial input.

Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain

The paper investigates the functional robustness of the HhH protein family under chiral inversion, finding functional ambidexterity across evolutionary trajectories.

Myonuclear alterations associated with exercise are independent of age in humans

This study shows that exercise-induced changes in myonuclear shape and stiffness occur independently of age in humans, potentially preserving muscle function across the lifespan.

An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium

This study develops an mRNA-LNP vaccine against Yersinia pestis, showing it provides full protection against infection in animals.

Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains

This study investigates how peptide-RNA coacervates influence the structure and dynamics of the HhH motif, suggesting they may have facilitated early protein evolution through oligomerization.

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

Phage therapy potentiates second-line antibiotic treatment against pneumonic plague

This paper shows that combining phage therapy with ceftriaxone improves survival in a mouse model of pneumonic plague caused by multidrug-resistant Yersinia pestis.

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines

A mathematical model of viral dynamics is used to identify mechanistic correlates of protection in SARS-CoV-2 vaccines across three non-human primate studies.

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

This study shows that subcutaneous vaccine administration leads to long-term phenotypic changes in blood neutrophils, unlike intradermal administration, highlighting the role of delivery route in immune training.

A framework to identify antigen-expanded T Cell Receptor (TCR) clusters within complex repertoires

This paper introduces a framework to identify antigen-specific TCR clusters in complex repertoires using deep sequencing and antigen-driven expansion, enabling personalized antigen assignment without cell isolation.

Fc-independent neutralization of SARS-CoV-2 by recombinant human monoclonal antibodies

This study shows that Fc-independent monoclonal antibodies can neutralize SARS-CoV-2 in mice, reducing viral load and preventing mortality without Fc-dependent effector functions.

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants

This study evaluates the neutralization potency of four SARS-CoV-2 mAbs against spike mutations and two variants of concern, finding that MD65 and BL6 retain effectiveness against B.1.1.7 and B.1.351.

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

This study identifies and characterizes neutralizing antibodies targeting the SARS-CoV-2 spike N-terminal domain, showing their protective efficacy in mice.

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

This study shows that the human monoclonal antibody MD65 can rescue 100% of SARS-CoV-2 infected mice when administered up to 3 days post-exposure.

Tiger team: a panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

This paper isolates and characterizes a panel of human neutralizing monoclonal antibodies targeting SARS-CoV-2 spike at multiple epitopes, suggesting their potential for combined post-exposure therapy.

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

This study identifies nuclear defects in nemaline myopathy caused by impaired contractility and cytoskeletal organisation in muscle fibres.