Author

M. Christgen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Kashiparekh· 1 shared A. V. Lee· 1 shared A. Wedn· 1 shared B. Clifford· 1 shared C. Veldman· 1 shared F. Chen· 1 shared I. J. Nijman· 1 shared J. Hooda· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Kashiparekh

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2 papers

Recent·Most cited

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic opportunities

O. S. Shah, F. Chen, A. Wedn, A. Kashiparekh, L. Savariau, B. Clifford, J. Hooda, M. Christgen, J. M. Atkinson, S. Oesterreich, A. V. Lee

The paper characterizes ILC and ILC-like cell lines through multi-omic analysis to identify molecular similarities with patient tumors and potential therapeutic targets.

bioRxiv · Sep 26, 2023 · PreprintCancer Biology

Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction

M. A. Ratze, L. N. Enserink, N. Ishiyama, C. Veldman, I. J. Nijman, R. R. Bernards, P. J. van Diest, M. Christgen, P. W. Derksen

This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.

bioRxiv · Jul 4, 2023 · PreprintCancer Biology