F. Chen

Association of Gene Variant Type and Location with Breast Cancer Risk in the General Population

This study evaluates breast cancer risks associated with pathogenic variant type and location in BRCA2 and other genes, finding differential risks based on variant position.

Establishing a Male-Positive Genetic Sexing Strain in the Asian Malaria Vector Anopheles stephensi

This paper applies the SEPARATOR system to Anopheles stephensi to enable male-specific genetic sexing for biocontrol, confirming evolutionary conservation of sex-specific splicing.

Diversified global vegetable oil production can mitigate climate change and achieve socio-environmental co-benefits

This paper assesses the environmental and economic impacts of global vegetable oil production and shows that diversification can reduce emissions and increase farmer income.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

This study profiles the DNA methylome of Pseudomonas syringae and shows its role in regulating virulence and metabolism through 6mA methylation.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration

This study identifies mDia2 as a mediator of MRTF-A-dependent breast cancer cell migration and links MRTF activity to malignancy, suggesting it as a therapeutic target.

Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner

This study shows that MRTF in breast cancer cells promotes osteoclast differentiation via paracrine signaling, enhancing bone metastasis, and suggests MRTF inhibition as a potential therapeutic strategy.

Emergence of multiphase condensates from a limited set of chemical building blocks

This study develops a theoretical framework to design multiphase biomolecular condensates from limited chemical building blocks and validates it through simulations.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

Loss of CTRP10 results in female obesity with preserved metabolic health

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

Entropic interfacial charge separation suppresses coarsening of nanoscale condensates

The paper identifies an entropic charge separation mechanism that limits coarsening in nanoscale condensates, explaining their long-term stability.

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic opportunities

The paper characterizes ILC and ILC-like cell lines through multi-omic analysis to identify molecular similarities with patient tumors and potential therapeutic targets.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

This study shows HER2 overexpression drives breast tumorigenesis by inducing oxidative stress in the tissue microenvironment, not directly in cancer stem cells.

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cells

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

EZH2 inhibition increases immune checkpoint inhibitor response in lung squamous cell carcinomas by enhancing antigen presentation and immune cell infiltration.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Overexpression of the violaxanthin de-epoxidase confers faster NPQ and photosynthesis induction in rice

This study shows overexpressing VDE in rice speeds up NPQ and photosynthesis induction, reduces photoinhibition, and increases biomass by 11-16% in field conditions.

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

This study shows ozone reduces malignant ascites in hepatocellular carcinoma by inhibiting NETs through AMPK activation and SR-A mediated phagocytosis of DAMPs.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Myeloid Zfhx3 Deficiency Protects Against Hypercapnia-induced Suppression of Host Defense Against Influenza A Virus

The paper shows that Zfhx3 deficiency in myeloid cells protects mice from hypercapnia-induced immune suppression and worsens influenza A virus infection.

Spatial transcriptomics maps molecular and cellular requirements for CD4+ T cell-dependent immunity to malaria.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.