Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse
L. Schmied, T. T. Luu, J. N. Sondergaard, S. Meinke, D. K. Mohammad, S. B. Singh, C. Mayer, G. Perinetti Casoni, M. Chrobok, H. Schlums, G. Rota, H. M. Truong, L. S. Westerberg, G. Guarda, E. Alici, , P. Hoglund
The paper shows that SHP-1 localization in NK cell synapses regulates tolerance in MHC class I-deficient cells through transcriptional and spatial mechanisms.
bioRxiv · Mar 8, 2022 · PreprintImmunology