M. D. Nicholson

Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications

The paper investigates phenotypic delay in bacterial antibiotic resistance evolution using simulations and theory, showing that dilution of sensitive molecules and effective polyploidy cause delay, affecting survival and mutation rate estimates.

Competing evolutionary paths in growing populations with applications to multidrug resistance

The paper models the emergence of resistant cell types in growing populations using branching processes on graphs, analyzing drug resistance scenarios in bacteria and cancer.