R. J. Allen

This study shows low-dose antibiotics trigger bacterial aggregation via lysis and extracellular DNA release, forming aggregates distinct from biofilms.

The paper presents a model showing how quorum sensing triggers stochastic biofilm formation through a transition between a loose bacterial layer and a growing biofilm.

This study develops a mathematical model to show that long-term and short-term urinary catheter colonization are controlled by different factors, suggesting tailored management strategies for infection prevention.

This study identifies two distinct types of multicellular aggregates in Pseudomonas aeruginosa cultures, mediated by different factors in exponential vs stationary phase.

This study uses simulations to show how active layer dynamics in biofilms lead to different structural phases, with pinning transitions affecting interface roughness and morphology.

This study measures the degradation half-lives of β-lactam antibiotics in bacterial growth media and highlights potential issues with interpreting MIC tests due to antibiotic instability.

The paper develops a mathematical model of fitness landscapes shaped by adaptational tradeoffs, showing predictable properties and accessible evolutionary paths despite ruggedness.

The paper investigates phenotypic delay in bacterial antibiotic resistance evolution using simulations and theory, showing that dilution of sensitive molecules and effective polyploidy cause delay, affecting survival and mutation rate estimates.

The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.

This study develops stochastic computational tools to analyze cell migration states, revealing two distinct migration states in MEFs and HeLa cells, linked to RhoG and Rac1 activity.