A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
V. T.-V. Dao, M. H. Elbatreek, M. Deile, P. I. Nedvetsky, A. Güldner, C. Ibarra, A. Gödecke, H. H. H. W. Schmidt
The paper shows NO-cGMP signaling is self-limiting through NO-induced sGC degradation, with implications for disease treatment using apo-sGC activators.
bioRxiv · Feb 6, 2020Pharmacology & Toxicology