Pharmacology & ToxicologybioRxiv
A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
V. T.-V. Dao, M. H. Elbatreek, M. Deile…·H. H. H. W. Schmidt
The paper shows NO-cGMP signaling is self-limiting through NO-induced sGC degradation, with implications for disease treatment using apo-sGC activators.
DOI 10.1038/s41598-020-66639-w