MEK inhibition causes Bim stabilization and sensitivity to Bcl2 family member inhibitors in RAS-MAPK mutated neuroblastoma
T. F. Eleveld, L. Vernooij, L. Schild, B. Koopmans, L. K. Alles, M. E. Ebus, P. G. van Sluis, H. N. Caron, J. Koster, R. Versteeg, E. M. Dolman, J. J. Molenaar
The paper identifies MEK inhibition combined with BCL2 family inhibitors as a potent treatment for RAS-MAPK mutated neuroblastoma by stabilizing Bim and increasing sensitivity to Bcl2 inhibitors.
bioRxiv · Feb 12, 2020 · PreprintCancer Biology