Cancer BiologybioRxivPreprint
MEK inhibition causes Bim stabilization and sensitivity to Bcl2 family member inhibitors in RAS-MAPK mutated neuroblastoma
T. F. Eleveld, L. Vernooij, L. Schild…·J. J. Molenaar
The paper identifies MEK inhibition combined with BCL2 family inhibitors as a potent treatment for RAS-MAPK mutated neuroblastoma by stabilizing Bim and increasing sensitivity to Bcl2 inhibitors.
DOI 10.1101/2020.02.12.945089