Morphological profiling of tubercule bacilli identifies drug pathways of action
T. C. Smith, K. M. Pullen, M. C. Olson, M. E. McNellis, I. Richardson, S. Hu, J. Larkins-Ford, X. Wang, J. S. Freundlich, D. M. Ando, B. Aldridge
This paper introduces MorphEUS, a morphological profiling method that classifies drugs based on their effects on Mycobacterium tuberculosis morphology, identifying both primary and off-target pathways of action.
bioRxiv · Mar 11, 2020Microbiology