The fitness effects of codon composition of the horizontally transferred antibiotic resistance genes intensify at sub-lethal antibiotic levels.
M. Shaferman, M. Gencel, N. Alon, K. Alasad, B. Rotblat, L. Alfonta, A. Serohijos, S. Bershtein
This study investigates how codon composition of horizontally transferred antibiotic resistance genes affects host fitness, finding that mRNA stability dominates over codon optimality at sub-lethal antibiotic levels.
bioRxiv · Feb 3, 2023Microbiology