Hydrogen-deuterium exchange coupled to top- and middle-down mass spectrometry enables high-resolution measurements of histone tail dynamics before and after nucleosome assembly
K. R. Karch, M. Coradin, L. Zandarashvili, Z.-Y. Kan, M. Gerace, S. W. Englander, B. E. Black, B. A. Garcia
This paper uses HDX-MS/MS with ETD to study histone tail dynamics before and after nucleosome assembly, achieving high-resolution deuterium localization.
bioRxiv · Apr 28, 2018Biochemistry