Author

B. E. Black

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:chromatin & epigenetic regulation· 7 Research Focus:cell type annotation· 4 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Organism:human· 2 Assay:proteomics· 2 Assay:structural biology· 2

Frequent Co-Authors

L. Zandarashvili· 2 shared A. Ali· 1 shared A. Das· 1 shared A. Sverzhinsky· 1 shared B. A. Garcia· 1 shared B. C. Creekmore· 1 shared D. Bensaddek· 1 shared D. Segura-Pena· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

L. Zandarashvili

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Author profile →

8 papers

Recent·Most cited

Native ultrastructure of fresh human brain vitrified directly from autopsy revealed by cryo-electron tomography with cryo-plasma focused ion beam milling

B. C. Creekmore, K. Kixmoeller, B. E. Black, E. B. Lee, Y.-W. Chang

This paper presents a method to image unfixed, never frozen human brain tissue using cryo-ET with xenon plasma FIB milling, revealing native ultrastructures like myelin and autophagy components.

bioRxiv · Sep 13, 2023 · PreprintPathology

Structural Basis for the Phase Separation of the Chromosome Passenger Complex

N. W. Bryan, A. Ali, E. Niedzialkowska, L. Mayne, P. T. Stukenberg, B. E. Black

The paper identifies contact regions in the chromosome passenger complex (CPC) that drive phase separation using hydrogen/deuterium-exchange mass spectrometry.

bioRxiv · May 22, 2023Biochemistry

Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

A. Das, K. G. Boese, K. Tachibana, S. H. Baek, M. A. Lampson, B. E. Black

This study shows that centromere-specifying nucleosomes persist in aging mouse oocytes without new assembly during prolonged prophase I arrest.

bioRxiv · May 18, 2023Cell Biology

The structural basis of the multi-step allosteric activation of Aurora B kinase

D. Segura-Pena, O. Hovet, H. Gogoi, J. M. Dawicki-McKenna, S. M. Hansen Woien, M. Carrer, B. E. Black, M. Cascella, N. Sekulic

This study investigates how phosphorylation in Aurora B and IN-box activates the [Aurora B/IN-box] complex through molecular dynamics and structural analysis.

bioRxiv · Nov 23, 2022Biochemistry

Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P

P. Mandal, Z. Yerkesh, V. Kharchenko, L. Zandarashvili, D. Bensaddek, L. Jaremko, B. E. Black, W. Fischle

This study identifies how PI5P allosterically activates UHRF1 to synergistically bind H3unmodified and H3K9me3 histone marks through conformational changes.

bioRxiv · Aug 4, 2021 · PreprintBiochemistry

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADPribose modifications

M.-F. Langelier, R. Billur, A. Sverzhinsky, B. E. Black, J. M. Pascal

This study shows HPF1 regulates PARP1/2 to balance initiation and elongation of ADP-ribose modifications, ensuring efficient serine modification during DNA damage response.

bioRxiv · May 19, 2021Biochemistry

Reconstitution of human kinetochore in mitotic cell extracts reveals permitted and restricted assembly steps

E. V. Tarasovetc, P. K. Allu, I. M. Cheeseman, B. E. Black, E. L. Grishchuk

bioRxiv · Jul 15, 2020Cell Biology

Hydrogen-deuterium exchange coupled to top- and middle-down mass spectrometry enables high-resolution measurements of histone tail dynamics before and after nucleosome assembly

K. R. Karch, M. Coradin, L. Zandarashvili, Z.-Y. Kan, M. Gerace, S. W. Englander, B. E. Black, B. A. Garcia

This paper uses HDX-MS/MS with ETD to study histone tail dynamics before and after nucleosome assembly, achieving high-resolution deuterium localization.

bioRxiv · Apr 28, 2018Biochemistry