SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells
M. Abrozek-Latecka, P. Kozlowski, G. Hoser, M. Bandyszewska, K. Hanusek, D. Nowis, J. Golab, M. Grzanka, A. Piekielko-Witkowska, L. Schulz, F. Hornung, S. Deinhardt-Emmer, E. Kozlowska, T. Skirecki
This study shows SARS-CoV-2 viroporins ORF3a, E, and M activate inflammasomes in macrophages and induce IL-1α release in pulmonary epithelial and endothelial cells, contributing to immunothrombosis in COVID-19.
bioRxiv · Nov 13, 2023 · PreprintImmunology