ImmunologybioRxivPreprint
SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells
M. Abrozek-Latecka, P. Kozlowski, G. Hoser…·T. Skirecki
This study shows SARS-CoV-2 viroporins ORF3a, E, and M activate inflammasomes in macrophages and induce IL-1α release in pulmonary epithelial and endothelial cells, contributing to immunothrombosis in COVID-19.
DOI 10.1101/2023.11.13.566917