Two antagonistic microtubule targeting drugs act synergistically to kill cancer cells
L. Peronne, E. Denarier, A. Rai, R. Prudent, A. Vernet, P. Suzanne, S. Ramirez-Rios, S. Michallet, M. Guidetti, J. Vollaire, D. Lucena-Agell, A.-S. Ribba, V. Josserand, J.-L. Coll, P. Dallemagne, , L. Lafanechere
The paper identifies Carba1, a microtubule-destabilizing drug, which synergizes with paclitaxel to enhance cancer cell killing in vitro and in vivo.
bioRxiv · Feb 6, 2020Cancer Biology