Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination
M. Gulkis, Q. Tang, M. Petrides, M. Caglayan
This study investigates how mutations in LIG1's active site affect its ability to discriminate between correct and mismatched DNA ends, revealing the role of DNA end rigidity in ligation fidelity.
bioRxiv · Mar 21, 2023 · PreprintBiochemistry