Increased prostaglandin-D2 in male but not female STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation
E. Stelling, M. Ricke-Hoch, S. Erschow, S. Hoffman, A. K. Bergmann, M. Heimerl, S. Pietzsch, K. Battmer, A. Haase, B. Stapel, M. Scherr, O. Binah, J.-L. Balligand, D. Hilfiker-Kleiner
This study shows that male STAT3-deficient hearts have increased PGD2 secretion, leading to epigenetic changes in cardiac progenitor cells that shift their differentiation from endothelial to white adipocyte.
PLOS Biology · Dec 28, 2020Peer-reviewedCell Biology