Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway
T. Sasahara, K. Satomura, M. Tada, A. Kakita, M. Hoshi
The paper shows patient-derived Aβ assemblies bind NAK3 on endothelial cells, inhibiting NO production and causing vascular dysfunction, and also contribute to neuronal damage through calcium overload.
bioRxiv · Dec 10, 2020Biochemistry