K. Otani

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

Plant specific armadillo repeat kinesin directs organelle transport and microtubule convergence to promote tip growth

This study identifies MpARK, a plant-specific kinesin, as essential for organelle transport and microtubule convergence in tip-growing rhizoids, supporting plant anchorage and growth.

Extracellular DJ-1 induces sterile inflammation in the ischemic brain

This paper shows that extracellular DJ-1 triggers inflammation in ischemic brains by activating TLR2 and TLR4, and that blocking DJ-1 reduces inflammation and neuronal damage.

Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats

This study uses a non-linear mixed effects model to analyze how single 60Co gamma ray exposures affect locomotor activity in rats, finding dose-dependent activity reduction and delayed recovery.

Changes in clock gene expression in esophagus in rat reflux esophagitis

This study examines how reflux esophagitis in rats affects circadian clock gene expression in the esophagus and other organs, finding disrupted circadian variability in several genes during acute and chronic phases.