Cancer BiologybioRxivPreprint
Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models
A. Lepland, A. Malfanti, U. Haljasorg…·P. Scodeller
This study develops a novel TAM-depleting agent, OximUNO, which targets CD206+ tumour macrophages in breast cancer models, reducing tumour growth and metastasis while showing low toxicity.
DOI 10.1101/2021.12.29.474487