P. Peterson

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Graves' disease-associated TSHR gene is demethylated and expressed in human regulatory T cells

The paper identifies hypomethylation and increased expression of the TSHR gene in regulatory T cells, but finds no methylation changes at the TSHR locus in Graves' disease patients.

IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

This study shows IL-34 deficiency impairs FOXP3+ Treg function, leading to autoimmunity and increased susceptibility to colitis and graft rejection.

Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models

This study develops a novel TAM-depleting agent, OximUNO, which targets CD206+ tumour macrophages in breast cancer models, reducing tumour growth and metastasis while showing low toxicity.

Aire-dependent transcripts escape H3K36me3 and Raver2 induced alternative splicing to sustain central immune tolerance

The paper identifies that Aire-sensitive genes in mTECs escape Raver2 and H3K36me3 regulation, leading to reduced alternative splicing and impacting central immune tolerance.