BiochemistrybioRxiv
A mutational atlas for Parkin proteostasis
L. Clausen, V. Voutsinos, M. Cagiada…·R. Hartmann-Petersen
This study maps Parkin missense variants' abundance and degradation mechanisms, showing most low-abundance variants are degraded via the ubiquitin-proteasome system and stabilized at lower temperatures.
DOI 10.1038/s41467-024-45829-4