Lipid nanoparticle structure and delivery route during pregnancy dictates mRNA potency, immunogenicity, and health in the mother and offspring
N. Chaudhary, A. N. Newby, M. L. Arral, S. S. Yerneni, S. T. LoPresti, R. Doerfler, D. M. S. Petersen, B. Fox, T. Coon, A. Malaney, Y. Sadovsky, K. A. Whitehead
This study identifies LNP structures that deliver mRNA effectively and safely during pregnancy, showing how their composition affects immunogenicity, maternal organ expression, and offspring health.
bioRxiv · Feb 15, 2023 · PreprintBioengineering