SPATEs promote the survival of Shigella to the plasma complement system upon hemorrhage and bacteremia
L. Debande, A. Sabbah, L. Kuhn, P. Ngondo, A. C. Andre, B. Roche, M. Laborde, M.-V. Cantalapiedra-Mateo, T. Thahouly, A. Milinski, L. Bianchetti, C. Allmang-Cura, M. Frugier, B. S. Marteyn
This study shows Shigella survives plasma exposure via SPATEs, which cleave C3 to impair complement activation, enhancing virulence during bacteremia.
bioRxiv · Nov 8, 2023 · PreprintMicrobiology